A deep dive into metabolic dysfunction in aging dogs for vets

In the last newsletter, we touched briefly on some of the mechanisms driving aging in dogs, and one of these was metabolic dysfunction. Since this is the key target of LOY-002, we wanted to explore this process in a bit more detail.  It turns out that deleterious changes in energy and lipid metabolism are a […]

Cover Image for The science behind lifespan extension: Metabolic dysfunction

The science behind lifespan extension: Metabolic dysfunction

As your dog ages, their metabolic health declines. This can undermine your dog’s quality of life and lead to multiple age-related diseases. Slowing or even reversing the loss of metabolic health can extend lifespan and maintain quality of life.

Cover Image for Linda Rhodes joins the Loyal Board of Directors

Linda Rhodes joins the Loyal Board of Directors

Loyal Founder and CEO Celine Halioua introduces our newest Board member, Linda Rhodes, DVM, PhD

Cover Image for Can science actually make your dog live longer? — the Purina study

Can science actually make your dog live longer? — the Purina study

Caloric restriction has been shown to extend dogs’ lifespans and improve their metabolic health, demonstrating that aging can be slowed — and we can do something about it. This knowledge drives research into more practical ways to achieve these benefits.

Cover Image for What is FDA conditional approval?

What is FDA conditional approval?

Expanded conditional approval is a new regulatory pathway that allows drugs to go to market more quickly, with the same rigorous safety standards.

Cover Image for $125M to extend dog lifespan

$125M to extend dog lifespan

Today we are announcing Loyal’s $45M Series B. Thank you, Wall Street Journal, for the excellent piece. This round brings Loyal’s total financing to over $125M. It is the honor of a lifetime to build Loyal with this team of scientists, veterinarians, creatives, operators, animal lovers, and investors.

Cover Image for Meet Boo — the first dog dosed in our LOY-002 pivotal study for extending healthy lifespan in dogs of nearly all sizes

Meet Boo — the first dog dosed in our LOY-002 pivotal study for extending healthy lifespan in dogs of nearly all sizes

The STAY study will span more than 50 sites across the country, with 1,000 senior dogs participating

Cover Image for Enrolling your dog in the STAY study

Enrolling your dog in the STAY study

Everything you need to know about study requirements and sites open for enrollment

Cover Image for Fetch KC recap: the questions so burning, curious vets stand in line to ask them

Fetch KC recap: the questions so burning, curious vets stand in line to ask them

A quick read from Dr. Ellen reflecting on her time spent talking with veterinary professionals about Loyal at a recent veterinary conference

Cover Image for Announcing our partnership with Crinetics Pharmaceuticals

Announcing our partnership with Crinetics Pharmaceuticals

Big implications for big dogs — and possibly humans, too

Cover Image for The power of big datasets

The power of big datasets

We collaborated with Banfield Pet Hospital to analyze the health records of 131,140 dogs in search of risk factors for age-related diseases

Cover Image for Approved drugs for veterinary patients are on a roll, y’all (why that’s got me in my feelings)

Approved drugs for veterinary patients are on a roll, y’all (why that’s got me in my feelings)

Take a trip down memory lane with me and celebrate recent wins in veterinary pharmaceutical development.

Cover Image for Our LOY-002 clinical pilot study is now fully enrolled

Our LOY-002 clinical pilot study is now fully enrolled

More momentum to share on our path to bringing dog longevity drugs to patients!

Cover Image for You and your dog share similarities in your blood: Exploring markers of aging

You and your dog share similarities in your blood: Exploring markers of aging

James is a Senior Scientist at Loyal who recently presented our findings in aging biomarkers at the Keystone Symposium 2023 conference. Here he explains how these biomarkers can help us better understand — and ultimately affect — the processes underlying aging

Cover Image for Vet education recap: Resources for canine geriatric medicine

Vet education recap: Resources for canine geriatric medicine

Dr. Brennen McKenzie often teaches continuing education courses around canine aging, and he shares resources that include foundational material on aging, clinical assessment tools, and guidelines to assist vets in creating treatment plans for senior dogs.

Cover Image for Loyal’s latest milestone: the first longevity clinical study design supported by the FDA

Loyal’s latest milestone: the first longevity clinical study design supported by the FDA

At Loyal we’re developing the first FDA-approved drugs explicitly intended to extend lifespan and healthspan, and being first means charting new waters.

On the path to FDA approval, we must run a clinical trial that objectively and robustly demonstrates that our drug extends dogs’ healthy lifespan, and does so safely. Because no one has developed a dog — or human — longevity drug before, we are building the path to FDA approval largely from scratch.

Last week we learned from the FDA that Loyal received protocol concurrence for our companion dog longevity study — likely the first time the FDA has given their blessing to a longevity clinical trial. Our regulatory expert Karen Greenwood weighs in on what this means for Loyal, for the field of aging, and for dogs everywhere.

Cover Image for How scientists measure aging through Healthspan, frailty and quality of life

How scientists measure aging through Healthspan, frailty and quality of life

Our Healthspan study results have been published in GeroScience. Let’s dive into the results.

Cover Image for Blake Scholl joins the Loyal Board of Directors

Blake Scholl joins the Loyal Board of Directors

Loyal Founder and CEO, Celine Halioua, introduces the newest addition to our Board of Directors

Cover Image for Why are modern dog breeds so different from one another?

Why are modern dog breeds so different from one another?

Does your dog have floppy ears or pointy ears, or maybe something in-between? History and biology explain why dogs come in all colors, patterns, shapes, and sizes.

Cover Image for How old is your dog, really? Predicting age through methylation

How old is your dog, really? Predicting age through methylation

We know biological samples can tell us about our dog’s health and breed ancestry, but is the saliva in your dog’s mouth enough to tell us your dog’s age and birthday? The answer is, in some ways, yes.

Cover Image for Ancestry & DNA: decipher the biology behind your dog’s family tree

Ancestry & DNA: decipher the biology behind your dog’s family tree

Each participant in the X-Thousand Dogs Study will receive a report with information about their dog’s ancestry. In this post, Loyal’s Dr. John Lindo, who specializes in ancient DNA and canine evolution, explains how our understanding of the relationships between species has changed over time and what a DNA test can—and cannot—reveal about your dog’s ancestors.

Cover Image for What is DNA methylation and how does it help us understand longevity?

What is DNA methylation and how does it help us understand longevity?

DNA methylation is a useful tool for assessing health and longevity—both in dogs and humans. Loyal scientists are studying aging through the lens of DNA methylation and epigenetics.

Cover Image for Your dog may be sharing bacteria with you. But that’s a good thing!

Your dog may be sharing bacteria with you. But that’s a good thing!

How are dogs like probiotics? Well, they’re cuter and furrier, but they also change our microbiome and can even reduce our risk of allergies! Let’s investigate how dogs influence our microbiome and our immune systems.

Cover Image for How to help your dog lose weight and improve their quality of life

How to help your dog lose weight and improve their quality of life

Discussing weight and how it impacts our dog’s health is important to how we think about our dog’s aging and quality of life. Here are practical tips and evidence-based advice to help your dog get to their healthiest weight.

Cover Image for How movement and exercise in dogs promotes longevity and healthier aging

How movement and exercise in dogs promotes longevity and healthier aging

How does movement impact longevity? Can physical activity help my dog live longer? Here’s how exercise maintains good health and slows aging.

Cover Image for Why do big dogs have unusually short lifespans compared to small dogs?

Why do big dogs have unusually short lifespans compared to small dogs?

Dogs come in an astounding range of shapes and sizes. Explore how genetic differences impact age and how Loyal is working on extending the lives and health of large dogs.

Cover Image for Signs of senior years: looking old, feeling old, and acting old

Signs of senior years: looking old, feeling old, and acting old

Do you ever wonder how your dog might look, feel, or act as they advance in age? Understanding aging gives us the potential to prevent or mitigate a wide range of age-related health problems in dogs.

Cover Image for Clinical trials in the real world: One practitioner’s perspective

Clinical trials in the real world: One practitioner’s perspective

Why I’d love to see general practitioners participate in clinical research: 5 compelling reasons from a former GP

Cover Image for Dog enrichment activities: Healthy brains and happy dogs

Dog enrichment activities: Healthy brains and happy dogs

Exercise and enrichment activities can help you protect your dog against the effects of brain aging.

Cover Image for Obesity and epigenetics

Obesity and epigenetics

One of the most important health problems in veterinary medicine today is the epidemic of obesity in our pets.

Cover Image for Healthspan: the healthy prime of life

Healthspan: the healthy prime of life

Lifespan is the amount of time lived. Healthspan is the time lived with vigor and good health. Which do you think is more important?

Cover Image for Should you zoom call your dog?

Should you zoom call your dog?

There are now lots of devices that let us call our dogs and say “Hi!” when we aren’t at home. But are these really for our dogs, or just for us?

Cover Image for Yes, dogs really can read facial expressions

Yes, dogs really can read facial expressions

Sometimes our dogs seem to read us like an open book! How do they know just how we are feeling? It turns out, our faces are a clear window into our emotions for our canine friends.

Cover Image for Talking to your dog?

Talking to your dog?

Dogs are exceptionally good at understanding humans; better than any animal outside our own species. But when we talk to them, we give a lot of information besides just words.

Cover Image for Dogs are great models for aging biology

Dogs are great models for aging biology

Dogs age a lot like humans, though sadly much faster. Helping us to better understand our own aging is just one of the many gifts our canine best friends give us.

Cover Image for Is aging inevitable?

Is aging inevitable?

Like death and taxes, aging has long been seen as unavoidable. Science is now showing us that this may not be true.

Cover Image for Can your dog catch your yawn?

Can your dog catch your yawn?

Humans are not the only animals to yawn. Fish, birds and mammals all yawn too. And, of course, so do our favorite animals here at Loyal!

Cover Image for Why do dogs age?

Why do dogs age?

There are many theories about how aging works. Lat’s take a brief look at two: Wear & Tear and the Rate of Living.

Cover Image for Aging and evolution

Aging and evolution

If evolution means survival of the fittest, shouldn’t animals evolve to stay healthy and live forever? Unfortunately, the evolutionary race goes to the most fertile, not the most enduring.

Cover Image for Two Loyal-nominated compounds selected for the National Institute on Aging Interventions Testing Program

Two Loyal-nominated compounds selected for the National Institute on Aging Interventions Testing Program

This collaboration will test the effectiveness of two important pro-longevity mechanisms and support development of aging drugs for dogs and beyond.

Cover Image for Quantifying the Aging Process: Loyal in-licenses mouse-canine-human homogeneous epigenetic clock from UCSD

Quantifying the Aging Process: Loyal in-licenses mouse-canine-human homogeneous epigenetic clock from UCSD

Loyal is developing an epigenetic clock to quantify biological aging in mice, dogs, and humans, spun out of the Ideker Laboratory at UCSD. This tech will support Loyal’s development of aging drugs for dogs and beyond.