Caloric restriction has been shown to extend dogs’ lifespans and improve their metabolic health, demonstrating that aging can be slowed — and we can do something about it. This knowledge drives research into more practical ways to achieve these benefits.
James is a Senior Scientist at Loyal who recently presented our findings in aging biomarkers at the Keystone Symposium 2023 conference. Here he explains how these biomarkers can help us better understand — and ultimately affect — the processes underlying aging
Dr. Brennen McKenzie often teaches continuing education courses around canine aging, and he shares resources that include foundational material on aging, clinical assessment tools, and guidelines to assist vets in creating treatment plans for senior dogs.
Does your dog have floppy ears or pointy ears, or maybe something in-between? History and biology explain why dogs come in all colors, patterns, shapes, and sizes.
Do you ever wonder how your dog might look, feel, or act as they advance in age? Understanding aging gives us the potential to prevent or mitigate a wide range of age-related health problems in dogs.
Dogs age a lot like humans, though sadly much faster. Helping us to better understand our own aging is just one of the many gifts our canine best friends give us.
As your dog ages, their metabolic health declines. This can undermine your dog’s quality of life and lead to multiple age-related diseases. Slowing or even reversing the loss of metabolic health can extend lifespan and maintain quality of life.
Caloric restriction has been shown to extend dogs’ lifespans and improve their metabolic health, demonstrating that aging can be slowed — and we can do something about it. This knowledge drives research into more practical ways to achieve these benefits.
One of the most important health problems in veterinary medicine today is the epidemic of obesity in our pets.
Big dog science
Large and giant breed dogs may live half the time of small breed dogs. LOY-001 and LOY-003 target the biological mechanisms thought to cause this lifespan disparity.
Dogs come in an astounding range of shapes and sizes. Explore how genetic differences impact age and how Loyal is working on extending the lives and health of large dogs.
If evolution means survival of the fittest, shouldn’t animals evolve to stay healthy and live forever? Unfortunately, the evolutionary race goes to the most fertile, not the most enduring.
Developing drugs
Learn about how we’re making progress toward approval from the FDA’s Center for Veterinary Medicine.
Many medications are used for both dogs and humans, but their effects can be quite different. Curious about why the effects vary so much between species? Dr. Brennen McKenzie teaches us about these fascinating differences.
Because our dogs share our environments and age like we do, we can learn about ourselves through our canine best friends — this is called translational medicine. Read about how the connection between us and our dogs can improve the health of both species.
Did you know there are several categories of medicines that your vet chooses from when prescribing a treatment to your dog? Each option comes with a different amount of evidence regarding risks and benefits. The FDA offers guidelines to help weigh the benefits and risks, making it easier for you and your vet to choose the right treatment.
We know biological samples can tell us about our dog’s health and breed ancestry, but is the saliva in your dog’s mouth enough to tell us your dog’s age and birthday? The answer is, in some ways, yes.
Each participant in the X-Thousand Dogs Study will receive a report with information about their dog’s ancestry. In this post, Loyal’s Dr. John Lindo, who specializes in ancient DNA and canine evolution, explains how our understanding of the relationships between species has changed over time and what a DNA test can—and cannot—reveal about your dog’s ancestors.
DNA methylation is a useful tool for assessing health and longevity—both in dogs and humans. Loyal scientists are studying aging through the lens of DNA methylation and epigenetics.
How are dogs like probiotics? Well, they’re cuter and furrier, but they also change our microbiome and can even reduce our risk of allergies! Let’s investigate how dogs influence our microbiome and our immune systems.
Discussing weight and how it impacts our dog’s health is important to how we think about our dog’s aging and quality of life. Here are practical tips and evidence-based advice to help your dog get to their healthiest weight.
Sometimes our dogs seem to read us like an open book! How do they know just how we are feeling? It turns out, our faces are a clear window into our emotions for our canine friends.
Dogs are exceptionally good at understanding humans; better than any animal outside our own species. But when we talk to them, we give a lot of information besides just words.
Today we are announcing Loyal’s $45M Series B. Thank you, Wall Street Journal, for the excellent piece. This round brings Loyal’s total financing to over $125M. It is the honor of a lifetime to build Loyal with this team of scientists, veterinarians, creatives, operators, animal lovers, and investors.
At Loyal we’re developing the first FDA-approved drugs explicitly intended to extend lifespan and healthspan, and being first means charting new waters.
Loyal is developing an epigenetic clock to quantify biological aging in mice, dogs, and humans, spun out of the Ideker Laboratory at UCSD. This tech will support Loyal’s development of aging drugs for dogs and beyond.
