Did you know there are several categories of medicines that your vet chooses from when prescribing a treatment to your dog? Each option comes with a different amount of evidence regarding risks and benefits. The FDA offers guidelines to help weigh the benefits and risks, making it easier for you and your vet to choose the right treatment.

As your dog ages, their metabolic health declines. This can undermine your dog’s quality of life and lead to multiple age-related diseases. Slowing or even reversing the loss of metabolic health can extend lifespan and maintain quality of life.

Loyal Founder and CEO Celine Halioua introduces our newest Board member, Linda Rhodes, DVM, PhD

Caloric restriction has been shown to extend dogs’ lifespans and improve their metabolic health, demonstrating that aging can be slowed — and we can do something about it. This knowledge drives research into more practical ways to achieve these benefits.

Expanded conditional approval is a new regulatory pathway that allows drugs to go to market more quickly, with the same rigorous safety standards.

Today we are announcing Loyal’s $45M Series B. Thank you, Wall Street Journal, for the excellent piece. This round brings Loyal’s total financing to over $125M. It is the honor of a lifetime to build Loyal with this team of scientists, veterinarians, creatives, operators, animal lovers, and investors.

The STAY study will span more than 50 sites across the country, with 1,000 senior dogs participating

Everything you need to know about study requirements and sites open for enrollment

A historic milestone in developing the first drug for healthy lifespan extension in dogs

A quick read from Dr. Ellen reflecting on her time spent talking with veterinary professionals about Loyal at a recent veterinary conference

Big implications for big dogs — and possibly humans, too

We collaborated with Banfield Pet Hospital to analyze the health records of 131,140 dogs in search of risk factors for age-related diseases

Take a trip down memory lane with me and celebrate recent wins in veterinary pharmaceutical development.

More momentum to share on our path to bringing dog longevity drugs to patients!

James is a Senior Scientist at Loyal who recently presented our findings in aging biomarkers at the Keystone Symposium 2023 conference. Here he explains how these biomarkers can help us better understand — and ultimately affect — the processes underlying aging

Dr. Brennen McKenzie often teaches continuing education courses around canine aging, and he shares resources that include foundational material on aging, clinical assessment tools, and guidelines to assist vets in creating treatment plans for senior dogs.

At Loyal we’re developing the first FDA-approved drugs explicitly intended to extend lifespan and healthspan, and being first means charting new waters.

Our Healthspan study results have been published in GeroScience. Let’s dive into the results.

Loyal Founder and CEO, Celine Halioua, introduces the newest addition to our Board of Directors

Does your dog have floppy ears or pointy ears, or maybe something in-between? History and biology explain why dogs come in all colors, patterns, shapes, and sizes.

We know biological samples can tell us about our dog’s health and breed ancestry, but is the saliva in your dog’s mouth enough to tell us your dog’s age and birthday? The answer is, in some ways, yes.

Each participant in the X-Thousand Dogs Study will receive a report with information about their dog’s ancestry. In this post, Loyal’s Dr. John Lindo, who specializes in ancient DNA and canine evolution, explains how our understanding of the relationships between species has changed over time and what a DNA test can—and cannot—reveal about your dog’s ancestors.

DNA methylation is a useful tool for assessing health and longevity—both in dogs and humans. Loyal scientists are studying aging through the lens of DNA methylation and epigenetics.

How are dogs like probiotics? Well, they’re cuter and furrier, but they also change our microbiome and can even reduce our risk of allergies! Let’s investigate how dogs influence our microbiome and our immune systems.

Discussing weight and how it impacts our dog’s health is important to how we think about our dog’s aging and quality of life. Here are practical tips and evidence-based advice to help your dog get to their healthiest weight.

How does movement impact longevity? Can physical activity help my dog live longer? Here’s how exercise maintains good health and slows aging.

Dogs come in an astounding range of shapes and sizes. Explore how genetic differences impact age and how Loyal is working on extending the lives and health of large dogs.

Do you ever wonder how your dog might look, feel, or act as they advance in age? Understanding aging gives us the potential to prevent or mitigate a wide range of age-related health problems in dogs.

Why I’d love to see general practitioners participate in clinical research: 5 compelling reasons from a former GP

Exercise and enrichment activities can help you protect your dog against the effects of brain aging.

One of the most important health problems in veterinary medicine today is the epidemic of obesity in our pets.

Lifespan is the amount of time lived. Healthspan is the time lived with vigor and good health. Which do you think is more important?

There are now lots of devices that let us call our dogs and say “Hi!” when we aren’t at home. But are these really for our dogs, or just for us?

Sometimes our dogs seem to read us like an open book! How do they know just how we are feeling? It turns out, our faces are a clear window into our emotions for our canine friends.

Dogs are exceptionally good at understanding humans; better than any animal outside our own species. But when we talk to them, we give a lot of information besides just words.

Dogs age a lot like humans, though sadly much faster. Helping us to better understand our own aging is just one of the many gifts our canine best friends give us.

Like death and taxes, aging has long been seen as unavoidable. Science is now showing us that this may not be true.

Humans are not the only animals to yawn. Fish, birds and mammals all yawn too. And, of course, so do our favorite animals here at Loyal!

There are many theories about how aging works. Lat’s take a brief look at two: Wear & Tear and the Rate of Living.

If evolution means survival of the fittest, shouldn’t animals evolve to stay healthy and live forever? Unfortunately, the evolutionary race goes to the most fertile, not the most enduring.

This collaboration will test the effectiveness of two important pro-longevity mechanisms and support development of aging drugs for dogs and beyond.

Loyal is developing an epigenetic clock to quantify biological aging in mice, dogs, and humans, spun out of the Ideker Laboratory at UCSD. This tech will support Loyal’s development of aging drugs for dogs and beyond.